Welcome to BrainStemX - Systems analysis of mammalian forebrain development
The SystemsX RTD project BrainstemX/NeurostemX started in March 2013 and has funding for four years. As part of the project six groups from developmental biology, computational biology, and engineering will work together to apply Systems-level approaches to understand the regulation of forebrain development.
The mammalian brain is the most complex organ in the animal kingdom. The cerebral cortex controls complex functions including cognition, motor control and memory. The increase in the complexity of the cerebral cortex across species has paralleled and probably driven the increased cognitive function throughout evolution. The cerebral cortex of mammals contains billions of cells and hundreds of functionally distinct neuron types generated from a thin sheet of neuroepithelial cells (neural stem cells). The maintenance of stem cell potential and the control of fate commitment during cortical development are regulated by dynamic signaling pathways that impact on transcription factor networks and intrinsic cellular programs in time and space. These key networks control the regimental differentiation and fate specification of neural stem cells required to form the precise structure of the cerebral cortex. A detailed understanding of the dynamic interplay between transcriptional networks and their upstream regulators will help our understanding brain formation and may enable the generation of defined cortical neurons populations.
The University of Basel and Department of Biosystems Science and Engineering of the Swiss Institute of Technology (ETH) invite applications from prospective Ph.D students and postdoctoral fellows. The successful candidates will work in a collaborative initiative between the two institutions to study development of the mammalian brain at the molecular and cellular systems biology level. The consortium is looking for highly motivated and experienced candidates ranging from cell and molecular biologists to those with experience in cell and tissue engineering and computational modeling. The project is based in Basel Switzerland and the successful candidates are expected to help to build a strong dynamic and interdisciplinary team between basic research, engineers and computational biologist. Apply »